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HTA-Proteases reveal novel blood biomarkers, both proteins and peptide hormones

Biomarkers only found with HTA Enzymes
Krakatoa-Vesuvius-Trypsin Venn Diagram

Krakatoa-Only : 46 High-confidence ID's
(> 3 precursors, > 90% of samples) 47 lower-confidence IDs

Coverage of 74 IDs common to trypsin and HTA-Proteases

Coverage of 74 ID's common to trypsin and HTA-Proteases

Simultaneous quantification of labile peptide hormones in the same LC-MS/MS run

Human Angiotensin graph

New biomarkers not seen with trypsin quantified with HTA-Proteases

Biomarker Discovery

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