Expand your proteomics capabilities
Antibody Sequencing
(De novo protein sequencing)
The fastest and highest-confidence de novo protein sequencing available. One HTA-enzyme, one LC-MS/MS run, in about one hour yielding 100% IgG sequence coverage with fewer errors.
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Isoleucine/Leucine disambiguation exploiting HTA-protease specificity
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Less Oxidation and Deamidation in HTA reactions
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More depth and confidence than multi enzyme approaches in a fraction of the time
Biomarker Discovery
HTA-Protease technologies reveal sequence and proteins not seen with traditional mesophilic enzymes also revealing PTM's on illuminated protein segments.
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Simultaneous quantitation of circulating proteins and labile peptide hormones
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100's of novel protein identifications relative to trypsin alone
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Non-overlapping peptide sets with trypsin and chymotrypsin
Difficult Proteins
HTA-Proteases generate data complimentary and orthogonal to mesophilic enzymes adding sequence information and increasing coverage of target proteins.
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HTA-Proteases are biased towards membrane and nuclear proteins relative to trypsin
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Additional coverage for over 50% of tryptic identifications
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Can reveal splice variants and PTM's not seen with traditional approaches
High Throughput Proteomics
The most rapid sample turnaround and interval yet reported for LC-MS/MS, requiring less than one hour to make quantitative biomarker measurements from blood.
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Reliable 15-minute sample preparation
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Automatable LC-MS/MS sample preparation for numerous sample types
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Direct digestion of cells, blood, serum, and plasma
Additional Classes of
HTA-Enzymes
CinderBio's proprietary platform uniquely enables access to the biodiversity of HyperThermoacidic Archaeal (HTA) genomes.
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HTA- Lipases, Proteases, Cellobiosidases, Cellulases, Xylanases, Xylobiosidases, Alpha-Amylases, Pullulanases, and others have been isolated and characterized.
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HTA-Enzymes can displace traditional chemicals for creating next generation biofuels and for cleaning and sanitation in food processing.