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Analyzing HTA-Protease LC-MS/MS data on PEAKS AB yields 100% sequence coverage in de novo IgG sequencing. Given the unique nature of HTA-Protease digestion conditions, the modification settings in the data analysis software will be different than for typical mesophilic enzymatic digestion. Bioinformatics Solutions Inc. (BSI) has published an App Note with helpful tips and tricks.
One Enzyme, One LC-MS/MS run, One-Hour, 100% sequence coverage, more redundancy with fewer errors.
Unparallelled Antibody Sequencing
The depth of redundant sequences is critical for accurate de novo protein sequencing. CinderBio's HTA-Proteases, Krakatoa and Vesuvius, provide over five times the redundancy of typical mesophilic enzymes, giving confidence that the sequence is accurate. All with less sample, less time, fewer errors, and superior coverage and depth.
CinderBio's one-enzyme, one-run de novo sequencing outperforms multi-enzyme approaches.
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